Malabsorption: A hidden cause of B12 deficiency

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Vitamin B12 occurs in animal foods bound to protein and gets released when hydrochloric acid and gastric protease in the stomach break this bond.

Eating disorders and chronic digestive disorders also make it difficult to absorb vitamin B12 from food.

These drugs are strongly linked to vitamin B12 deficiency since users of these medications lack adequate stomach acid to break down and absorb vitamin B12.

In a very small portion of the population, vitamin B12 deficiency is caused by a lack of intrinsic factor, a protein secreted by the stomach lining that binds to vitamin B12 and enables its absorption.

This can lead to pernicious anemia, a decrease in red blood cells that occurs when the intestines cannot properly absorb vitamin B12.

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