Long term health benefits of Vitamin B12

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Vitamin B12 has been associated with the development of age related macular degeneration (AMD) and risk of frailty, both leading causes of disability in the elderly.

Frailty is characterized by muscle wasting, diminished strength, often with weight loss with or without reduced nutritional intake. Frailty is associated with an increased vulnerability to stresses, causing longer and more complicated recovery from illness or surgery.

Low vitamin B12 status has been postulated as a potential risk factor for neural tube defects (NTD) since vitamin B12 acts as a cofactor for methionine synthase in the folate cycle. When vitamin B12 supply is low, the folate needed for DNA synthesis remains trapped in the methylation cycle and cell replication is impaired.

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